Disruption in oligodendrocyte function indicated in schizophrenia
نویسندگان
چکیده
منابع مشابه
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Disrupted-in-schizophrenia 1 (DISC1) was initially discovered through a balanced translocation (1;11)(q42.1;q14.3) that results in loss of the C terminus of the DISC1 protein, a region that is thought to play an important role in brain development. Here, we use an inducible and reversible transgenic system to demonstrate that early postnatal, but not adult induction, of a C-terminal portion of ...
متن کاملSleep and circadian rhythm disruption in schizophrenia†
BACKGROUND Sleep disturbances comparable with insomnia occur in up to 80% of people with schizophrenia, but very little is known about the contribution of circadian coordination to these prevalent disruptions. AIMS A systematic exploration of circadian time patterns in individuals with schizophrenia with recurrent sleep disruption. METHOD We examined the relationship between sleep-wake acti...
متن کاملOligodendrocyte pathophysiology: a new view of schizophrenia.
A recent focus of schizophrenia research is disruption of white-matter integrity as a key facet of this complex disorder. This was spurred, partly, by new imaging modalities, magnetic transfer imaging and diffusion tensor imaging, which showed differences in white-matter integrity and tract coherence in persons with schizophrenia compared to controls. Oligodendrocytes, in particular, have been ...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2001
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20010426-01